Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 107
Filtrar
1.
BMC Ecol Evol ; 24(1): 22, 2024 Feb 14.
Artigo em Inglês | MEDLINE | ID: mdl-38355429

RESUMO

BACKGROUND: Biological adaptation manifests itself at the interface of different biologically relevant 'levels', such as ecology, performance, and morphology. Integrated studies at this interface are scarce due to practical difficulties in study design. We present a multilevel analysis, in which we combine evidence from habitat utilization, leaping performance and limb bone morphology of four species of tamarins to elucidate correlations between these 'levels'. RESULTS: We conducted studies of leaping behavior in the field and in a naturalistic park and found significant differences in support use and leaping performance. Leontocebus nigrifrons leaps primarily on vertical, inflexible supports, with vertical body postures, and covers greater leaping distances on average. In contrast, Saguinus midas and S. imperator use vertical and horizontal supports for leaping with a relatively similar frequency. S. mystax is similar to S. midas and S. imperator in the use of supports, but covers greater leaping distances on average, which are nevertheless shorter than those of L. nigrifrons. We assumed these differences to be reflected in the locomotor morphology, too, and compared various morphological features of the long bones of the limbs. According to our performance and habitat utilization data, we expected the long bone morphology of L. nigrifrons to reflect the largest potential for joint torque generation and stress resistance, because we assume longer leaps on vertical supports to exert larger forces on the bones. For S. mystax, based on our performance data, we expected the potential for torque generation to be intermediate between L. nigrifrons and the other two Saguinus species. Surprisingly, we found S. midas and S. imperator having relatively more robust morphological structures as well as relatively larger muscle in-levers, and thus appearing better adapted to the stresses involved in leaping than the other two. CONCLUSION: This study demonstrates the complex ways in which behavioral and morphological 'levels' map onto each other, cautioning against oversimplification of ecological profiles when using large interspecific eco-morphological studies to make adaptive evolutionary inferences.


Assuntos
Ecossistema , Saguinus , Animais , Adaptação Biológica
2.
Commun Biol ; 6(1): 995, 2023 09 28.
Artigo em Inglês | MEDLINE | ID: mdl-37770611

RESUMO

Eco-morphological convergence, i.e., similar phenotypes evolved in ecologically convergent taxa, naturally reproduces a common-garden experiment since it allows researchers to keep ecological factors constant, studying intrinsic evolutionary drivers. The latter may result in differential evolvability that, among individual anatomical parts, causes mosaic evolution. Reconstructing the evolutionary morphology of the humerus and femur of slow arboreal mammals, we addressed mosaicism at different bone anatomical spatial scales. We compared convergence strength, using it as indicator of evolvability, between bone external shape and inner structure, with the former expected to be less evolvable and less involved in convergent evolution, due to anatomical constraints. We identify several convergent inner structural traits, while external shape only loosely follows this trend, and we find confirmation for our assumption in measures of convergence magnitude. We suggest that future macroevolutionary reconstructions based on bone morphology should include structural traits to better detect ecological effects on vertebrate diversification.


Assuntos
Evolução Biológica , Árvores , Animais , Mamíferos/genética , Fenótipo
4.
Nat Commun ; 14(1): 3594, 2023 06 16.
Artigo em Inglês | MEDLINE | ID: mdl-37328455

RESUMO

Cancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious, almost all protein-coding genes lack detectable signals of negative selection. This raises the question of how tumors tolerate such large amounts of deleterious mutations. Using 8,690 tumor samples from The Cancer Genome Atlas, we demonstrate that copy number amplifications frequently cover haploinsufficient genes in mutation-prone regions. This could increase tolerance towards the deleterious impact of mutations by creating safe copies of wild-type regions and, hence, protecting the genes therein. Our findings demonstrate that these potential buffering events are highly influenced by gene functions, essentiality, and mutation impact and that they occur early during tumor evolution. We show how cancer type-specific mutation landscapes drive copy number alteration patterns across cancer types. Ultimately, our work paves the way for the detection of novel cancer vulnerabilities by revealing genes that fall within amplifications likely selected during evolution to mitigate the effect of mutations.


Assuntos
Variações do Número de Cópias de DNA , Neoplasias , Humanos , Neoplasias/genética , Genoma , Mutação
5.
Acta fisiátrica ; 30(2): 129-135, jun. 2023.
Artigo em Português | LILACS-Express | LILACS | ID: biblio-1516446

RESUMO

Infrared thermography is a technique used for complementary diagnosis of pain, through the presentation of thermal images with an infrared sensor that assesses body surface temperature. Pressure algometry is an objective method that seeks to quantify pain at specific points. Both techniques have been employed for diagnostic purposes. Objective: To review the literature on publications that addressed the use of thermography and algometry in combination as an assessment tool in studies of evaluation of pain. Method: This was a systematic review conducted on Pubmed, Bireme and Scielo databases, using the following descriptors: "thermography" AND "pain threshold", and "thermography" AND "pain tolerance", without limitation of publication date, in English and Portuguese, in September 2020. Eligibility criteria for the studies were: use of thermography in combination with algometry in aimed at the outcome of temperature variation in chronic painful processes in humans. Results: The search resulted in thirty-two studies, and after abstract analysis, twenty-two were excluded for not meeting inclusion criteria. The remaining ten were read in full and made up the present review. Conclusion: Although few studies have employed both techniques in the same diagnostic assessment method, the use of algometry and thermography in combination may provide objective measures of subjective symptoms, which can bring a great contribution to the diagnostic accuracy and clinical monitoring of patients affected by painful processes.


A termografia infravermelha é uma técnica utilizada para diagnóstico complementar da dor, através da apresentação de imagens térmicas com uma câmera infravermelha que mensura a temperatura da superfície do corpo. A algometria de pressão é um método objetivo que busca quantificar a dor em pontos determinados. Ambas as técnicas vem sido empregadas para finalidades diagnósticas. Objetivo: Revisar a literatura acerca das publicações que abordaram a utilização da termografia e algometria em conjunto como instrumentos de avaliação da dor. Método: Trata-se de uma revisão sistemática nas bases de dados Pubmed, Bireme e Scielo utilizando os seguintes descritores: "thermography" AND "pain threshold", e "termografia" AND "tolerância à dor", sem limitação por data de publicação, em inglês e português, no mês de setembro de 2022. Os critérios de elegibilidade para os estudos foram: utilização da termografia em conjunto com a algometria na busca do desfecho variação da temperatura em processos dolorosos crônicos em seres humanos. Resultados: A busca resultou em trinta e dois estudos, e após a análise dos resumos, vinte e dois foram excluídos por não preencherem os critérios de inclusão, restando dez que foram lidos na íntegra e que compuseram a presente revisão. Conclusão: Apesar da algometria e termografia se apresentarem como técnicas pragmaticamente válidas no estudo da dor, esta revisão mostrou que poucos estudos incluíram em seu desenho a combinação destas técnicas como instrumentos de avaliação.

6.
Curr Rev Musculoskelet Med ; 15(6): 629-636, 2022 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-36301514

RESUMO

PURPOSE OF REVIEW: This study is a narrative review aiming at evaluating the current literature of the last 5 years on gamification and musculoskeletal rehabilitation. The article search involved the following MeSH terms at PubMed: "gamification," "exergaming," and "rehabilitation." Original studies in English language were included. RECENT FINDINGS: After careful analysis of the search results, 17 articles were included in this review. The use of games for rehabilitation was investigated in musculoskeletal rehabilitation conditions such as shoulder surgery, impingement syndrome, rheumatoid arthritis, osteoarthritis, low back pain, fibromyalgia, fracture, and ligament reconstruction. Results were similar or superior to conventional physical therapy or home-based exercises, with the additional benefit of improving motivation to the exercise program. Improvements in quality of life and perceived health status were also observed. The cost-effectiveness of this type of technology was also mentioned as an advantage of exergames in musculoskeletal rehabilitation. Studies involving gamification in musculoskeletal rehabilitation stress the potential of this resource in several aspects of physical fitness, health, and quality of life, also improving motivation and adherence to the exercise treatment.

7.
J Rehabil Med ; 54: jrm00342, 2022 Nov 29.
Artigo em Inglês | MEDLINE | ID: mdl-36254624

RESUMO

OBJECTIVE: The incidence of spinal cord injury in Brazil is increasing. It is important to understand more about how individuals are living with spinal cord injury. DESIGN: Cross-sectional, observational study of individuals with spinal cord injury in south-eastern Brazil. SUBJECTS: A questionnaire with 125 questions was applied to individuals diagnosed with spinal cord injury. Participants were recruited by survey team from 2 rehabilitation centres (both in south-eastern Brazil) that treat persons diagnosed with SCI. Personal characteristics, associated health conditions, quality of life, work status, environmental factors, and other functioning-related aspects were evaluated. RESULTS: A total of 201 individuals participated in the survey. Of these, 79% were male, mean age 44 years, 60% were considered paraplegic, and the major causes of impairment were firearm injuries and road traffic accidents. Spasticity was the most frequently reported health condition, followed by neuropathic pain. 50% of subjects did not report any difficulty with participation in activities of daily living. However, only approximately 10% of subjects returned to work after spinal trauma. Their quality of life is reported 44% as good. CONCLUSION: Most people with spinal cord injury in south-eastern Brazil are male and paraplegic, health problems and spasticity is considered their most problematic health condition. Although they report having a good quality of life, they still encounter disabling environmental barriers that make their life more difficult, such as poor accessibility of public spaces, and only a small proportion (10%) returned to work after their injury. This study provides an initial overview of the lived experience of people with spinal cord injury in south-eastern Brazil and should serve as a starting point for future research on this population.


Assuntos
Armas de Fogo , Traumatismos da Medula Espinal , Ferimentos por Arma de Fogo , Masculino , Humanos , Adulto , Feminino , Atividades Cotidianas , Qualidade de Vida , Estudos Transversais , Brasil/epidemiologia , Ferimentos por Arma de Fogo/complicações , Traumatismos da Medula Espinal/reabilitação , Paraplegia/etiologia , Paraplegia/reabilitação , Espasticidade Muscular/etiologia
8.
Food Res Int ; 154: 111012, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-35337570

RESUMO

The demand for sustainably produced proteins is increasing with the world population and is prompting a dietary shift toward plant sourced proteins. Vegetable proteins have lower digestibility and biological value compared to animal derived counterparts. We explored sprouting of chickpea seeds as a strategy for improving digestibility. Protein evolution associated with by the sprouting process was assessed by proteomics. The sprouting induced breakdown of seed storage proteins and doubled the release of free alpha-amino nitrogen in sprouted chickpea flour. During sprouting, several enzymes involved in plant development were newly expressed. An ex vivo model of gastroduodenal and jejunal digestion was applied to assess the bioaccessibility of the protein digests. Proteins from chickpea sprouts showed a greater susceptibility to digestion with a 10% increase in alpha amino nitrogen. Peptides with potential immunoreactivity or bioactivity were catalogued in both digested chickpea sprouts and seeds using an in-silico approach. Peptides belonging to the non-specific transfer proteins, which are allergens in pulses, and peptides belonging to an IgE-binding hemagglutinin protein could only be identified in the digested chickpea sprouts. The observation collected paved the way to immune-based evaluations to assess the effect of germination on the allergenic potential.


Assuntos
Cicer , Animais , Digestão , Farinha , Microvilosidades , Proteoma/metabolismo
9.
Acta fisiátrica ; 29(1): 1-5, mar. 2022.
Artigo em Português | LILACS-Express | LILACS | ID: biblio-1354745

RESUMO

Medidas alternativas e de baixo custo podem ser importantes para análise do movimento humano. Objetivo: Verificar a concordância de análise de movimento humano entre aplicativo de monitoramento por meio de inteligência artificial com análise tridimensional de movimento. Método: Estudo transversal observacional no qual voluntário sadio realizou movimentos de: flexão dos braços, flexão de cotovelos, flexão de tronco, inclinação de tronco e sentar e levantar. As imagens foram captadas por meio de sistema de análise tridimensional do movimento por câmeras infravermelhas e pelo aplicativo da Linkfit por meio de dois dispositivos móveis (smartphones). Foram comparados os ângulos estimados pelo aplicativo da Linkfit com os ângulos correspondentes medidos pelo sistema de análise tridimensional do movimento. Para comparar os ângulos da LinkFit com os ângulos mensurados pelo laboratório tridimensional de movimento, o teste de causalidade de Granger foi usado para cada série paralela dos dados. Resultados: A utilização de técnicas de visão computacional e deep learning para detecção de movimento utilizando câmeras de celular mostrou um grau de concordância de 84% em relação à medidas geradas por análise tridimensional de movimento realizadas em laboratório. Conclusão: A utilização de técnicas de visão computacional e deep learning é promissora para a realização de estudos que envolvem a detecção do movimento do corpo humano, quando comparadas com medidas de padrão-ouro de análise de movimento, podendo ser portanto, uma alternativa. Estudos futuros devem ser realizados utilizando maior número de voluntários e movimentos, com o intuito de consolidar os resultados obtidos nesse estudo.


Alternative and low-cost measures may be important for analyzing human movement. Objective: The objective of this study was to verify the agreement of human movement analysis of a monitoring app that uses artificial intelligence compared to three-dimensional movement analysis. Methods:Observational cross-sectional case report study in which a healthy volunteer performed arm flexion, elbow flexion, trunk flexion, lateral trunk bending, and sitting and standing. Images of the volunteer were simultaneously captured by a three-dimensional movement analysis system based on infrared cameras and the Linkfitapp of two mobile devices (smartphones). The body angles estimated by the Linkfitapp were compared with the corresponding angles measured by the three-dimensional movement analysis system. The Granger causality test was used to compare the pairs of angles for each parallel data series. Results:The use of smartphone cameras and deep learning techniques for motion detection had an 84% degree of agreement compared to measurements generated by the three-dimensional movement analysis performed in the laboratory. Conclusion:The use of smartphone cameras and deep learning techniques is promising for conducting studies for body movement detection compared to the gold standard measures of movement analysis. This technology may become an alternative for movement analysis. Future studies should consider a more significant number of volunteers and model movements to strengthen the results obtained in this study.

10.
Acta fisiátrica ; 28(4): 285-289, dez. 2021.
Artigo em Português | LILACS-Express | LILACS | ID: biblio-1352412

RESUMO

O programa de reabilitação em regime de internação pode trazer diversos benefícios aos indivíduos amputados. Objetivo: Verificar a temperatura dos membros inferiores e a funcionalidade de indivíduo amputado submetido a um programa de reabilitação em regime de internação. Método: Paciente do sexo masculino com amputação transfemoral distal à esquerda foi avaliado por meio da termografia (infrared sensor FLIR T650sc) da região da coxa, teste Timed Up and Go, teste de caminhada de 2 minutos e a Escala AMP - Amputee Mobility Predictor antes e após programa de internação para reabilitação durante 4 semanas. Resultados: Em relação a avaliação termográfica, houve diminuição da diferença de temperatura entre as coxas direita e esquerda, passando de 1,9°C para 0,6°C na vista anterior e de 3,4°C para 0,3°C na vista posterior após o programa de reabilitação. O tempo de execução do TUG passou de 17,17 s para 13,08 s e a escala AMP passou de 38 para 43 após o programa de reabilitação. Conclusão: Indivíduo amputado unilateral de membro inferior submetido a programa de 4 semanas de reabilitação em regime de internação pode ser beneficiado em relação a simetria de distribuição da temperatura cutânea da coxa, mobilidade funcional e funcionalidade.


The inpatient rehabilitation program can bring several benefits to amputees. Objective: Verify the temperature of the lower limbs and the functionality of the amputee individual submitted to an inpatient rehabilitation program. Method: Male patient with left distal transfemoral amputation was evaluated by thermography (FLIR T650sc infrared sensor) of the thigh region, Timed Up and Go test, 2-minute walk test and after an inpatient program for rehabilitation for 4 weeks. Results: Regarding the thermographic evaluation, there was a decrease in the temperature difference between the right and left thighs, going from 1.9 °C to 0.6 °C in the anterior view and from 3.4 °C to 0.3 °C in posterior view after rehabilitation program. The TUG execution time went from 17.17 s to 13.08 s and an AMP scale went from 38 to 43 after the rehabilitation program. Conclusion: The amputee individual lower limb unilateral submitted to a 4-week inpatient rehabilitation program may benefit from symmetry in the distribution of skin temperature in the thigh, functional mobility and functionality.

11.
BrJP ; 4(3): 221-224, July-Sept. 2021. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1339291

RESUMO

ABSTRACT BACKGROUND AND OBJECTIVES: Massage is described as an effective complementary therapy for relieving muscle tension and pain. The aim of this study was to verify the benefits of quick massage on muscle tension and pressure pain tolerance threshold (PPT). METHODS: A randomized clinical study in which 40 professors participated and were randomly divided into control (CG) and experimental (EG) groups. They were assessed for the level of muscle tension in the shoulder and neck regions using the visual analogue scale (VAS). PPT was assessed through algometry at the upper trapezius and sternocleidomastoid muscles and at the following anatomical areas: base of the occipital, scapular spine, thoracic (T6-T7) and lumbar (L4-L5) regions. The EG received a single session of quick massage for 20 minutes on the shoulders, neck and spine. RESULTS: Regarding pain, a significant difference was observed only at the base of the occipital, the EG presented greater tolerance to pressure pain both before and after the intervention when compared to the CG. Regarding muscle tension, after the intervention, there was a reduction in the perception in the EG compared to the CG group. CONCLUSION: Quick massage was efficient to decrease the perception of muscle tension assessed by VAS, however, PPT did not increase after the intervention.


RESUMO JUSTIFICATIVA E OBJETIVOS: A massagem é descrita como terapia complementar efetiva no alívio de dor e tensão muscular. O objetivo deste estudo foi verificar os benefícios da Quick Massage sobre a tensão muscular e o limiar de tolerância de dor à pressão (LTDP). MÉTODOS: Estudo clínico randomizado que incluiu 40 docentes divididos aleatoriamente em grupo controle (GC) e grupo experimental (GE). Eles foram avaliados quanto ao nível de tensão muscular na região dos ombros e pescoço por meio da escala analógica visual (EAV). O LTDP foi avaliado por algometria sobre os músculos trapézio superior e esternocleidomastóideo e nos seguintes pontos anatômicos: base do occipital, espinha da escápula, região torácica (T6-T7) e região lombar (L4-L5). O GE recebeu uma única sessão de Quick Massage por 20 minutos na região dos ombros, pescoço e coluna vertebral. RESULTADOS: Em relação à dor, somente na base do occipital foi verificada diferença significante, o GE apresentou maior tolerância de dor à pressão tanto antes quanto após a intervenção em relação ao GC. Em relação à tensão muscular, após a intervenção, houve redução da percepção no GE em relação ao grupo GC. CONCLUSÃO: A Quick Massage foi eficiente para diminuir a percepção da tensão muscular, contudo, o limiar de tolerância de dor à pressão não aumentou após a intervenção.

12.
BrJP ; 4(3): 225-231, July-Sept. 2021. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1339299

RESUMO

ABSTRACT BACKGROUND AND OBJECTIVES: Chronic pain represents a relevant public health problem due to its high global prevalence, high costs of medical care, complexity of the treatment and loss of productive capacity. In Brazil, there are few population-based studies regarding chronic pain and associated factors, thus, the aim of this study was to evaluate the prevalence and factors associated with chronic pain among residents of urban and rural regions of the city of Irani-SC. METHODS: Cross-sectional population study, with random sampling, stratified by sex and age, in which 409 residents participated. Data was collected by individual interview, sociodemographic and clinical questionnaires, and application of a lifestyle profile instrument. RESULTS: The prevalence of chronic pain was 56% of the population. The most frequent associated factors were: female sex, being married, living in urban area, older age, more years of work, a higher number of children, fewer vacation periods in the last year, low schooling, higher body mass index, low coffee consumption and a higher number of comorbidities when compared to the group without chronic pain (p<0.05). There was no significant difference between groups regarding lifestyle. CONCLUSION: Prevalence of chronic pain was high when compared to that found by other studies. Chronic pain was more prevalent in women, married, white, and urban residents. Possible predictors of this condition were age, years of work, number of children, vacation days in the last 12 months, number of cups of coffee consumed per day, body mass index and number of comorbidities.


RESUMO JUSTIFICATIVA E OBJETIVOS: A dor crônica representa relevante problema de saúde pública pela alta prevalência, custo de cuidados médicos, complexidade de tratamento e perda da capacidade produtiva. No Brasil, há poucos estudos populacionais sobre dor crônica e fatores associados, assim, o objetivo deste estudo foi avaliar a prevalência e fatores associados à dor crônica entre os residentes das regiões urbana e rural da cidade de Irani-SC. MÉTODOS: Estudo transversal populacional, com amostragem aleatória, estratificada por sexo e idade, do qual participaram 409 pessoas. Os dados foram coletados por entrevista individual, questionários sociodemográfico e clínico e aplicação de instrumento de perfil de estilo de vida. RESULTADOS: A prevalência de dor crônica foi de 56%. Os fatores associados mais frequentes foram: sexo feminino, ser casado, morar em área urbana, idade mais avançada, mais anos trabalhados, maior número de filhos, menos períodos de férias no último ano, baixa escolaridade, consumo de menos xícaras de café por dia, maior índice de massa corporal e maior número de comorbidades quando comparados ao grupo sem dor crônica (p<0,05). Não houve diferença significante entre os grupos em relação ao estilo de vida. CONCLUSÃO: A prevalência de dor crônica foi alta quando comparada à encontrada por estudos correlatos. Foi mais prevalente em mulheres, indivíduos casados, brancos e residentes em área urbana. Possíveis preditores desta condição foram idade, anos trabalhados, número de filhos, dias de férias no último ano, número de xícaras de café consumidos por dia, índice de massa corporal e número de comorbidades.

13.
Front Neurorobot ; 15: 684019, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34366819

RESUMO

Background: Stroke is one of the leading causes of adult disability, and up to 80% of stroke survivors undergo upper extremity motor dysfunction. Constraint-Induced Movement Therapy (CIMT) and Robot-Assisted Therapy (RT) are used for upper limb stroke rehabilitation. Although CIMT and RT are different techniques, both are beneficial; however, their results must be compared. The objective is to establish the difference between RT and CIMT after a rehabilitation program for chronic stroke patients. Method: This is a randomized clinical trial, registered at ClinicalTrials.gov (ID number NCT02700061), in which patients with stroke received sessions of RT or CIMT protocol, combined with a conventional rehabilitation program for 12 weeks. The primary outcome was measured by Wolf Motor Function Test (WMFT) and Fugl-Meyer Assessment-Upper Limb (FMA-UL). Activities of daily living were also assessed. Results: Fifty one patients with mild to moderate upper limb impairment were enrolled in this trial, 25 women and 26 men, mean age of 60,02 years old (SD 14,48), with 6 to 36 months after stroke onset. Function significantly improved regardless of the treatment group. However, no statistical difference was found between both groups as p-values of the median change of function measured by WMFT and FMA were 0.293 and 0.187, respectively. Conclusion: This study showed that Robotic Therapy (RT) was not different from Constraint-Induced Movement Therapy (CIMT) regardless of the analyzed variables. There was an overall upper limb function, motor recovery, functionality, and activities of daily living improvement regardless of the interventions. At last, the combination of both techniques should be considered in future studies.

14.
Clinics (Sao Paulo) ; 76: e2804, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34133481

RESUMO

OBJECTIVES: As patients recovering from the novel coronavirus disease 2019 (COVID-19) present with physical, respiratory, cognitive, nutritional, and swallowing-related impairments and mental health complications, their rehabilitation needs are complex. This study aimed to describe the demographic, clinical, and functional status after the discharge of COVID-19 survivors who underwent intensive multidisciplinary inpatient rehabilitation at the Physical and Rehabilitation Medicine Institute of the University of Sao Paulo Medical School General Hospital and Lucy Montoro Rehabilitation Institute. We determined the most important factors related to the length of inpatient rehabilitation treatment and present the functional outcomes. METHODS: This was a retrospective study based on electronic medical records. In addition to the severity of COVID-19 and length of hospital stay for the management of COVID-19 and comorbidities, we collected sociodemographic data including age, sex, height, and weight. Functional assessments were performed using the Functional Independence Measure (FIM); Short Physical Performance Battery; Montreal Cognitive Assessment; Depression, Anxiety and Stress Scale; Revised Impact of Events Scale; bioelectrical impedance; Functional Oral Intake Scale; oropharyngeal dysphagia classification; and nutritional assessment. RESULTS: There was a significant improvement in FIM before and after inpatient rehabilitation treatment (p<0.0001). Muscle strength and walking capacity were significantly improved (p<0.01). The most important factors related to the length of inpatient rehabilitation treatment were improvement in FIM scores (Spearman's r=0.71) and gain in lean mass (Spearman's r=0.79). CONCLUSIONS: Rehabilitation of patients after COVID-19 recovery improves their functional status and should be considered in the post-acute phase for selected patients with COVID-19.


Assuntos
COVID-19 , Medicina Física e Reabilitação , Humanos , Tempo de Internação , Recuperação de Função Fisiológica , Estudos Retrospectivos , SARS-CoV-2 , Resultado do Tratamento
15.
Sci Rep ; 11(1): 10106, 2021 05 12.
Artigo em Inglês | MEDLINE | ID: mdl-33980917

RESUMO

Patients with sequelae of stroke commonly report somatosensory losses. It is believed that body temperature may be associated with tactile sensibility and sensorimotor recovery of these patients. Demonstrate the associations among tactile sensibility, cutaneous temperature, subjective temperature perception, and sensorimotor recovery of patients with stroke sequelae. 86 patients with stroke sequelae were included. Patients had standardized regions of interest (ROIs) assessed with infrared thermography (FLIR T650SC) and monofilaments esthesiometry, and global motor recovery was evaluated with Fugl-Meyer Assessment (FMA). The presence of self-reported perception of temperature difference was used to divide the participants into two groups of 43 patients, and correlation tests were applied to establish correlations among variables. There is no clinically relevant association between tactile sensibility and cutaneous temperature of the foot, regardless of the subjective sensation of temperature changes. Sensorimotor recovery evaluated by FMA is associated with the difference of sensibility between both sides of the body (p < 0.001), as well as with the difference of tactile sensibility (p < 0.001). A clinically significant association between the difference of cutaneous temperature and tactile sensibility was not found, regardless of the presence or absence of subjective perception of such temperature difference. However, sensorimotor recovery is correlated with cutaneous temperature differences and tactile sensibility.


Assuntos
Temperatura Corporal , Sensação , Acidente Vascular Cerebral/fisiopatologia , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Recuperação de Função Fisiológica , Temperatura Cutânea , Acidente Vascular Cerebral/psicologia , Termografia , Percepção do Tato
16.
Am J Phys Anthropol ; 175(4): 920-930, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-33811768

RESUMO

OBJECTIVES: The advent of micro-computed tomography (µCT) made cancellous bone more accessible than ever before. Nevertheless, the characterization of cancellous bone is made difficult by its inherent complexity and the difficulties in defining homology across datasets. Here we propose novel virtual methodological approaches to overcome those issues and complement existing methods. MATERIALS AND METHODS: We present a protocol for the isolation of the whole cancellous region within a µCT scanned bone. This method overcomes the subsampling issues and allows studying cancellous bone as a single unit. We test the protocol on a set of primate bones. In addition, we describe a set of morphological indices calculated on the topological skeleton of the cancellous bone: node density, node connectivity, trabecular angle, trabecular tortuosity, and fractal dimension. The usage of the indices is shown on a small comparative sample of primate femoral heads. RESULTS: The isolation protocol proves reliable in isolating cancellous structures from several different bones, regardless of their shape. The indices seem to detect some functional differences, although further testing on comparative samples is needed to clarify their potential for the study of cancellous architecture. CONCLUSIONS: The approaches presented overcome some of the difficulties of trabecular bone studies. The methods presented here represent an alternative or supporting method to the existing tools available to address the biomechanics of cancellous bone.


Assuntos
Osso Esponjoso , Primatas , Animais , Fenômenos Biomecânicos , Densidade Óssea , Osso Esponjoso/diagnóstico por imagem , Cabeça do Fêmur , Microtomografia por Raio-X
17.
Evolution ; 75(2): 542-554, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33314086

RESUMO

Convergent evolution is a major topic in evolutionary biology. Low bone cortical compactness (CC, a measure of porosity of cortical bone) in the extant genera of "tree sloths," has been linked to their convergent slow arboreal ecology. This proposed relationship of low CC with a slow arboreal lifestyle suggests potential convergent evolution of this trait in other slow arboreal mammals. Femoral and humeral CC were analyzed in "tree sloths," lorisids, koala, and extinct palaeopropithecids and Megaladapis, in comparison to closely related but ecologically distinct taxa, in a phylogenetic framework. Low CC in "tree sloths" is unparalleled by any analyzed clade and the high CC in extinct sloths suggests the recent convergence of low CC in "tree sloths." A tendency for low CC was found in Palaeopropithecus and Megaladapis. However, lorisids and the koala yielded unexpected CC patterns, preventing the recognition of a straightforward convergence of low CC in slow arboreal mammals. This study uncovers a complex relationship between CC and convergent evolution of slow arboreality, highlighting the multifactorial specificity of bone microstructure.


Assuntos
Evolução Biológica , Osso Cortical , Locomoção , Bichos-Preguiça/genética , Animais , Bichos-Preguiça/anatomia & histologia
18.
Clinics ; 76: e2804, 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1278938

RESUMO

OBJECTIVES: As patients recovering from the novel coronavirus disease 2019 (COVID-19) present with physical, respiratory, cognitive, nutritional, and swallowing-related impairments and mental health complications, their rehabilitation needs are complex. This study aimed to describe the demographic, clinical, and functional status after the discharge of COVID-19 survivors who underwent intensive multidisciplinary inpatient rehabilitation at the Physical and Rehabilitation Medicine Institute of the University of Sao Paulo Medical School General Hospital and Lucy Montoro Rehabilitation Institute. We determined the most important factors related to the length of inpatient rehabilitation treatment and present the functional outcomes. METHODS: This was a retrospective study based on electronic medical records. In addition to the severity of COVID-19 and length of hospital stay for the management of COVID-19 and comorbidities, we collected sociodemographic data including age, sex, height, and weight. Functional assessments were performed using the Functional Independence Measure (FIM); Short Physical Performance Battery; Montreal Cognitive Assessment; Depression, Anxiety and Stress Scale; Revised Impact of Events Scale; bioelectrical impedance; Functional Oral Intake Scale; oropharyngeal dysphagia classification; and nutritional assessment. RESULTS: There was a significant improvement in FIM before and after inpatient rehabilitation treatment (p<0.0001). Muscle strength and walking capacity were significantly improved (p<0.01). The most important factors related to the length of inpatient rehabilitation treatment were improvement in FIM scores (Spearman's r=0.71) and gain in lean mass (Spearman's r=0.79). CONCLUSIONS: Rehabilitation of patients after COVID-19 recovery improves their functional status and should be considered in the post-acute phase for selected patients with COVID-19.


Assuntos
Humanos , Medicina Física e Reabilitação , COVID-19 , Estudos Retrospectivos , Resultado do Tratamento , Recuperação de Função Fisiológica , SARS-CoV-2 , Tempo de Internação
19.
Estud. interdiscip. envelhec ; 26(3): 227-240, dez.2021.
Artigo em Português | LILACS, Index Psicologia - Periódicos | ID: biblio-1425229

RESUMO

Introdução: são escassos os estudos a respeito das relações entre força muscular, composição corporal e estado nutricional de idosos. Objetivo: avaliar as relações entre força de preensão manual, composição corporal e estado nutricional de idosos da comunidade. Métodos: setenta e nove idosos sedentários de ambos os sexos, frequentadores do Centro de Convivência do Idoso em Embu-Guaçu/SP, participaram deste estudo transversal quantitativo. Eles foram submetidos à avaliação de força de preensão manual por dinamometria, de composição corporal por bioimpedância tetrapolar, e do estado nutricional pelo índice de massa corporal e pela Mini Avaliação Nutricional reduzida. Resultados: a preensão manual direta foi considerada adequada em 65,8% da amostra. A maior parte dos idosos apresentava excesso de peso (60,3%) e de adiposidade (76,9% dos homens e 85,9% das mulheres), e 53,8% dos homens apresentavam sarcopenia grau I vs. 27,7% das mulheres. Um terço da amostra (34,2%) apresentava risco de desnutrição. O valor energético médio consumido pela amostra foi significantemente mais alto entre os homens (p=0,005), que também apresentaram menor ingestão percentual de carboidratos (p=0,03), e maior ingestão de proteínas (p<0,0001) e lipídeos (p=0,01) do que as mulheres. A força de preensão manual direita esteve moderadamente associada à massa magra (r=0,54 e p<0,001) e fracamente associada ao consumo de proteínas (r=0,330 e p=0,01). Conclusão: houve associação entre força de preensão manual, massa magra e consumo de proteínas, porém não foram encontradas associações entre a força e o escore da avaliação nutricional ou o índice de massa corporal.(AU)


Introduction: studies on the relationships between muscle strength, body composition, and nutritional status of the elderly are still scarce. Objective: to evaluate the relationship between manual grip strength, body composition, and nutritional status of community-dwelling elderly. Methods: seventy-nine sedentary elderly men and women from the Center for the Elderly in Embu-Guaçu/SP participated in this quantitative cross-sectional study. Participants were submitted to handgrip strength evaluation by dynamometry, body composition by tetrapolar bioelectrical impedance, and nutritional status by the body mass index and reduced Mini Nutritional Assessment. Results: right-hand grip strength was considered adequate in 65.8% of the sample. Most elderly presented excessive body weight (60,3%) and adiposity (76,9% of men e 85,9% of women). 53.8% of men presented with stage I sarcopenia vs. 27.7% of women. One-third (34.2%) of the elderly presented risk of malnutrition. The mean energy consumed by the sample was significantly higher among males (p=0.005), who also presented lower percentage of carbohydrate intake (p=0.03) and higher intake of proteins (p<0.0001) and lipids (p=0.01) than women. Right-hand grip strength was moderately associated with lean mass (r=0.54 and p<0.001) and weakly associated protein consumption (r=0.330 and p=0.01). Conclusion: there was an association between handgrip strength, lean mass, and protein intake, however, no asso -ciations were found between strength and nutritional assessment scores or body mass index.(AU)


Assuntos
Composição Corporal , Idoso , Avaliação Nutricional , Saúde do Idoso , Força Muscular
20.
BrJP ; 3(4): 322-327, Oct.-Dec. 2020. tab
Artigo em Inglês | LILACS-Express | LILACS | ID: biblio-1153253

RESUMO

ABSTRACT BACKGROUND AND OBJECTIVES: Knee osteoarthritis is among the leading sources of chronic disability and may lead to depression, anxiety and pain catastrophizing, enhancing perceived pain. This study aimed at investigating the influence of pain catastrophizing on attitudes and perception of pain, and in the functionality of individuals with knee osteoarthritis. METHODS: This observational study involved 18 patients, who were assessed for weight and height, and completed the Pain-related Catastrophizing Thoughts Scale (PCTS), Survey of Pain Attitudes (SPA), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the visual analog scale (VAS). Symptoms and disability were assessed by the Lequesne Index, functional mobility was evaluated by the Timed Up and Go (TUG) test. Pressure pain tolerance thresholds (PPT) were assessed by a digital algometer. RESULTS: Mean body mass index of the sample was classified as obese (32,2±4,3). When split by the median of PCTS, differences were observed in most domains of SPA. Patients with more catastrophic thoughts took longer to perform TUG and presented more pain, joint stiffness and worse functionality (WOMAC). Despite the tendency to report more pain (VAS) in patients above the median score of PCTS, no differences were observed between groups with higher or lower catastrophizing regarding PPT. Positive and significant associations between the Rumination factor of PCTS and WOMAC outcomes were observed, as well as between the Hopelessness factor and TUG, Lequesne and WOMAC. CONCLUSION: The higher the presence of catastrophic thoughts, the worse the attitudes towards pain and the physical functionality of knee osteoarthritis patients.


RESUMO JUSTIFICATIVA E OBJETIVOS: A osteoartrite do joelho está entre as principais causas de incapacidade crônica e pode levar à depressão, ansiedade e catastrofização, intensificando a percepção da dor. Este estudo teve como objetivo investigar a influência da catastrofização da dor nas atitudes e na percepção da dor e a funcionalidade de indivíduos com osteoartrite do joelho. MÉTODOS: Dezoito pacientes foram avaliados quanto ao peso e à estatura, e completaram a Escala de Pensamentos Catastróficos Sobre a Dor (EPCD), Inventário de Atitudes frente à Dor (IAD), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) e escala analógica visual (EAV). Os sintomas e a incapacidade foram avaliados pelo Índice de Lequesne, a mobilidade funcional foi avaliada pelo teste Timed Up and Go (TUG). Os limiares de tolerância à dor à pressão (LTDP) foram avaliados por um algômetro digital. RESULTADOS: A média do índice de massa corporal da amostra foi classificado como obesa (32,2±4,3). Quando divididas pela mediana do EPCD, foram observadas diferenças na maioria dos domínios do IAD. Pacientes com pensamentos mais catastróficos demoraram mais para realizar o TUG e apresentaram mais dor, rigidez articular e pior funcionalidade (WOMAC). Apesar da tendência de relatar mais dor (EAV) em pacientes acima do escore mediano do EPCD, não foram observadas diferenças entre os grupos com maior ou menor catastrofização em relação aos LTDP. Foram observadas associações positivas e significantes entre o fator ruminação da EPCD e o WOMAC, bem como entre o fator Desesperança e TUG, Lequesne e WOMAC. CONCLUSÃO: Quanto maior a presença de pensamentos catastróficos, piores as atitudes em relação à dor e funcionalidade física dos pacientes com osteoartrite do joelho.

SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...